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SCIENTIFIC PAPERS

The following scientific papers have been published and may be downloaded from the journal websites, if the appropriate registrations and administrative requirements with the publishers have been fulfilled.

  • Enhanced release of itraconazole from ordered mesoporous SBA-15 silica materials
    Randy Mellaerts, Caroline A. Aerts, Jan Van Humbeeck, Patrick Augustijns, Guy Van den Mooter and Johan A. Martens, Chem. Commun., 2007, 1375–1377.
  • Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica Randy Mellaerts, Raf Mols, Jasper A.G. Jammaer, Caroline A. Aerts, Pieter Annaert, Jan Van Humbeeck, Guy Van den Mooter, Patrick Augustijns, Johan A. Martens, European Journal of Pharmaceutics and Biopharmaceutics 69 (2008) 223–230
  • Ordered mesoporous silica induces pH-independent supersaturation of the basic low solubility compound itraconazole resulting in enhanced transepithelial transport Randy Mellaerts, Raf Mols, Pieterjan Kayaert, Pieter Annaert, Jan Van Humbeeck, Guy Van den Mooter , Johan A. Martens, Patrick Augustijns. International Journal of Pharmaceutics 357 (2008) 169–179
  • Physical State of Poorly Water Soluble Therapeutic Molecules Loaded into SBA-15 Ordered Mesoporous Silica Carriers: A Case Study with Itraconazole and Ibuprofen Randy Mellaerts, Jasper A. G. Jammaer, Michiel Van Speybroeck, Hong Chen, Jan Van Humbeeck, Patrick Augustijns, Guy Van den Mooter, and Johan A. Martens. Langmuir 2008, 24, 8651-8659
  • Ordered Mesoporous Silica Material SBA-15: A Broad-Spectrum Formulation Platform for Poorly Soluble Drugs
    Michiel Van Speybroeck, Valery Barillaro, Thoa Do Thi, Randy Mellaerts, Johan Martens, Jan Van Humbeeck, Jan Vermant, Pieter Annaert, Guy Van den Mooter, Patrick Augustijns. Journal of Pharmaceutical Sciences, Vol. 98, No. 8, Aug 2009
  • Aging behavior of pharmaceutical formulations of itraconazole on SBA-15 ordered mesoporous silica carrier material Randy Mellaerts, Kristof Houthoofd , Ken Elen, Hong Chen, Michiel Van Speybroeck, Jan Van Humbeeck, Patrick Augustijns, Jules Mullens, Guy Van den Mooter, Johan A. Martens. Microporous and Mesoporous Materials 130 (2010) 154–161
  • Combined use of ordered mesoporous silica and precipitation inhibitors for improved oral absorption of the poorly weak base itraconazole Van Speybroeck, M., Mols, R., Mellaerts, R., Do Thi, T., Martens, J., Van Humbeeck, J., Annaert, P., Van den Mooter, G., Augustijns, P. (2010) European Journal of Pharmaceuticas and Biopharmaceutics, 76, 364-365
  • Enhanced absorption of the poorly soluble drug fenofibrate by tuning its release rate from ordered mesoporous silica Van Speybroeck, M., Mols, R., Mellaerts, R., Do Thi, T., Martens, J., Van Humbeeck, J., Annaert, P., Van den Mooter, G., Augustijns, P. (2010) European Journal of Pharmaceutical Sciences, 41, 623-630
  • Preventing release in the acidic environment of the stomach via occlusion in ordered mesoporous silica enhances the absorption of poorly soluble weakly acidid drugs Van Speybroeck, M., Mols, R., Mellaerts, R., Do Thi, T., Martens, J., Van Humbeeck, J., Annaert, P., Van den Mooter, G., Augustijns, P. (2010) Journal of Pharmaceutical Sciences, 100, 11, 4864-4876